Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin
Identifieur interne : 000049 ( 1957/Analysis ); précédent : 000048; suivant : 000050Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin
Auteurs : Cyrille Dreyfus ; Damian C. Ekiert ; Ian A. WilsonSource :
- Journal of Virology [ 0022-538X ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (), Anticorps antiviraux (immunologie), Anticorps monoclonaux (), Anticorps monoclonaux (immunologie), Anticorps neutralisants (), Anticorps neutralisants (immunologie), Cristallographie aux rayons X, Données de séquences moléculaires, Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (immunologie), Grippe humaine (virologie), Humains, Modèles moléculaires, Pandémies, Réactions croisées, Souris, Sous-type H2N2 du virus de la grippe A (immunologie), Séquence d'acides aminés, Tests de neutralisation, Virus de la grippe A (), Virus de la grippe A (immunologie), Épitopes (), Épitopes (immunologie).
- MESH :
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sous-type H2N2 du virus de la grippe A, Virus de la grippe A, Épitopes.
- virologie : Grippe humaine.
- Animaux, Anticorps antiviraux, Anticorps monoclonaux, Anticorps neutralisants, Cristallographie aux rayons X, Données de séquences moléculaires, Humains, Modèles moléculaires, Pandémies, Réactions croisées, Souris, Séquence d'acides aminés, Tests de neutralisation, Virus de la grippe A, Épitopes.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Antibodies, Monoclonal (chemistry), Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (chemistry), Antibodies, Neutralizing (immunology), Antibodies, Viral (chemistry), Antibodies, Viral (immunology), Cross Reactions, Crystallography, X-Ray, Epitopes (chemistry), Epitopes (immunology), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (immunology), Influenza A virus (classification), Influenza A virus (immunology), Influenza, Human (immunology), Influenza, Human (virology), Mice, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Pandemics.
- MESH :
- chemical , chemistry : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus.
- classification : Influenza A virus.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A virus, Influenza, Human.
- virology : Influenza, Human.
- Amino Acid Sequence, Animals, Cross Reactions, Crystallography, X-Ray, Humans, Mice, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Pandemics.
Abstract
We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.
Url:
DOI: 10.1128/JVI.02975-12
PubMed: 23552413
PubMed Central: 3676097
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000488
- to stream Pmc, to step Curation: 000488
- to stream Pmc, to step Checkpoint: 000562
- to stream PubMed, to step Corpus: 000125
- to stream PubMed, to step Curation: 000125
- to stream PubMed, to step Checkpoint: 000106
- to stream Ncbi, to step Merge: 000891
- to stream Ncbi, to step Curation: 000891
- to stream Ncbi, to step Checkpoint: 000891
- to stream Main, to step Merge: 000826
- to stream Main, to step Curation: 000825
- to stream Main, to step Exploration: 000825
- to stream 1957, to step Extraction: 000049
Links to Exploration step
PMC:3676097Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin</title><author><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23552413</idno><idno type="pmc">3676097</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676097</idno><idno type="RBID">PMC:3676097</idno><idno type="doi">10.1128/JVI.02975-12</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000488</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000488</idno><idno type="wicri:Area/Pmc/Curation">000488</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000488</idno><idno type="wicri:Area/Pmc/Checkpoint">000562</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000562</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:23552413</idno><idno type="wicri:Area/PubMed/Corpus">000125</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000125</idno><idno type="wicri:Area/PubMed/Curation">000125</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000125</idno><idno type="wicri:Area/PubMed/Checkpoint">000106</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000106</idno><idno type="wicri:Area/Ncbi/Merge">000891</idno><idno type="wicri:Area/Ncbi/Curation">000891</idno><idno type="wicri:Area/Ncbi/Checkpoint">000891</idno><idno type="wicri:doubleKey">0022-538X:2013:Dreyfus C:structure:of:a</idno><idno type="wicri:Area/Main/Merge">000826</idno><idno type="wicri:Area/Main/Curation">000825</idno><idno type="wicri:Area/Main/Exploration">000825</idno><idno type="wicri:Area/1957/Extraction">000049</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin</title><author><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Antibodies, Monoclonal (chemistry)</term><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Neutralizing (chemistry)</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (chemistry)</term><term>Antibodies, Viral (immunology)</term><term>Cross Reactions</term><term>Crystallography, X-Ray</term><term>Epitopes (chemistry)</term><term>Epitopes (immunology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A virus (classification)</term><term>Influenza A virus (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Neutralization Tests</term><term>Pandemics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux ()</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps monoclonaux ()</term><term>Anticorps monoclonaux (immunologie)</term><term>Anticorps neutralisants ()</term><term>Anticorps neutralisants (immunologie)</term><term>Cristallographie aux rayons X</term><term>Données de séquences moléculaires</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe humaine (immunologie)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Modèles moléculaires</term><term>Pandémies</term><term>Réactions croisées</term><term>Souris</term><term>Sous-type H2N2 du virus de la grippe A (immunologie)</term><term>Séquence d'acides aminés</term><term>Tests de neutralisation</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (immunologie)</term><term>Épitopes ()</term><term>Épitopes (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Epitopes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Epitopes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Anticorps neutralisants</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe humaine</term><term>Sous-type H2N2 du virus de la grippe A</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Cross Reactions</term><term>Crystallography, X-Ray</term><term>Humans</term><term>Mice</term><term>Models, Molecular</term><term>Molecular Sequence Data</term><term>Neutralization Tests</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Anticorps neutralisants</term><term>Cristallographie aux rayons X</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Modèles moléculaires</term><term>Pandémies</term><term>Réactions croisées</term><term>Souris</term><term>Séquence d'acides aminés</term><term>Tests de neutralisation</term><term>Virus de la grippe A</term><term>Épitopes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We report the structural characterization of the first antibody identified to cross-neutralize multiple subtypes of influenza A viruses. The crystal structure of mouse antibody C179 bound to the pandemic 1957 H2N2 hemagglutinin (HA) reveals that it targets an epitope on the HA stem similar to those targeted by the recently identified human broadly neutralizing antibodies. C179 also inhibits the low-pH conformational change of the HA but uses a different angle of approach and both heavy and light chains.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Dreyfus, Cyrille" sort="Dreyfus, Cyrille" uniqKey="Dreyfus C" first="Cyrille" last="Dreyfus">Cyrille Dreyfus</name><name sortKey="Ekiert, Damian C" sort="Ekiert, Damian C" uniqKey="Ekiert D" first="Damian C." last="Ekiert">Damian C. Ekiert</name><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A." last="Wilson">Ian A. Wilson</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000049 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000049 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= 1957
|étape= Analysis
|type= RBID
|clé= PMC:3676097
|texte= Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i -Sk "pubmed:23552413" \
| HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |